姓名：唐娟

学位：博士

导师情况：博士生导师

研究领域：谱系示踪与心血管再生

E-mail: tangjuan@tongji.edu.cn

通讯地址：上海市杨浦区四平路1239号，正规nba买球正规nba买球，邮编200092

研究方向：

1. 研究心血管疾病再生过程中的各类细胞命运变化及作用机制。

2. 探索心脏再生修复中的分子机制，提供治疗心脏损伤的新靶点。

3. 开发遗传谱系示踪新技术，为心血管再生研究提供新工具。

个人简介：

2011年毕业于华中农业大学，获得学士学位。2017年毕业于中国科学院营养与健康研究院，获得理学博士学位。2017-2021年在中国科学院分子细胞科学卓越创新中心从事博士后和副研究员工作。主要研究心血管疾病与细胞命运的谱系变化，系统的阐明了在心血管疾病的再生和修复中细胞的命运变化及分子机制，从而探索促进心血管再生和修复的有效策略。2021年7月起任正规nba买球正规nba买球“百人计划”特聘研究员，博士生导师。目前以（共同）第一作者和（共同）通讯作者在Cell Stem Cell、 Circulation、 Cell Research、Circulation Research等国际学术期刊上发表论文11篇，曾获得中国博士后创新人才计划、中国科协“青年人才托举计划”等项目支持。

代表文章（*Co-first authors; #Corresponding authors）：

1. Tang J*^#, Zhu H*, Tian X*, Wang H, Liu S, Liu K, Zhao H, He L, Huang X, Feng Z, Ding Z, Long B, Yan Y, Nicola S, Gong H, Luo Q^#, Zhou B^#. Extension of Endocardium-derived Vessels Generate Coronary Arteries in Neonates. Circulation Research. 2022;130;352-365.

2. Lu Z, Jiang Z, Tang J^#, Lin C^#, Zhang H^#. Functions and origins of cardiac fat. The FEBS Journal. 2022.10.111/febs.16388.

3. Tang J*, Zhu H*, Wang H, Huang X, Zhou B^#. Sca1 marks a reserve endothelial progenitor population that preferentially expand after injury. Cell Discovery. 2021 Sep 28;7(1):88.

4. Tang J*, Wang H*, Huang X*, Li F*, Zhu H, Li Y, He L, Zhao H, Pu W, Liu, K, Zhang H, Bentzo J, Yu Y, Ji Y, Nie Y, Tian X, Zhang L^#, Gao D^#, Zhou B^#. Arterial Sca1⁺ vascular stem cells generate de novo smooth muscle for artery repair and regeneration. Cell Stem Cell. 2020;26: 81-96.

5. Tang J, Li Y, Huang X, He L, Zhang L, Wang H, Yu W, Tian X, Nie Y, Hu S, Lui KO, Zhou B^#. Fate mapping of sca1⁺ cardiac progenitor cells in the adult mouse heart. Circulation. 2018;138(25):2967–2969.

6. Tang J, Zhang H, He L, Huang X, Li Y, Pu W, Yu W, Zhang L, Cai D, Lui KO, Zhou B^#. Genetic fate mapping defines the vascular potential of endocardial cells in the adult heart. Circulation Research. 2018;122: 984-993.

7. Tang J, Shen Y, Chen G, Wan Q, Wang K, Zhang J, Qin J, Liu G, Zuo S, Tao B, Yu Y, Wang J, Lazarus M, Yu Y^#. Activation of e-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nature Communications. 2017; 8:14656.

8. Jin H*, Liu K*, Tang J*, Huang X, Wang H, Zhang Q, Zhu H, Li Y, Pu W, Zhao H, He L, Li Y, Zhang S, Zhang Z, Zhao Y, Qin Y, Pflanz S, Kasmi K, Zhang W, Liu Z, Ginhoux F, Ji Y, He B, Wang L, Zhou B^#. Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury. Nature Communications. 2021; 12, 2863 (2021).

9. Yan S*, Tang J*, Zhang Y, Wang Y, Zuo S, Shen Y, Zhang Q, Chen D, Yu Y, Wang K, Duan SZ, Yu Y^#. Prostaglandin e2 promotes hepatic bile acid synthesis by an e prostanoid receptor 3-mediated hepatocyte nuclear receptor 4alpha/cholesterol 7alpha-hydroxylase pathway in mice. Hepatology. 2017;65: 999-1014.

10. Zhang H*, Huang X*, Liu K*, Tang J*, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO, Zhou B^#. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Research. 2017;27: 1157-1177.

11. Chen D*, Tang J*, Wan Q, Zhang J, Wang K, Shen Y^#, Yu Y^#. E-prostanoid 3 receptor mediates sprouting angiogenesis through suppression of the protein kinase a/beta -catenin /notch pathway. Arteriosclerosis, Thrombosis, and Vascular biology. 2017;37: 856-866.