姓        名：刘文强

学        位：博士

导师情况：博士生导师

研究领域：发育与生殖生物学

研究方向：

1．哺乳动物及人早期胚胎发育调控。 
2．胚胎发育异常的机制及干预。 
3．不育不孕的遗传学机制及辅助生殖技术。
E-mail：liuwenqiang@tongji.edu.cn
联系电话：021-65982276
通讯地址：上海市四平路1239号正规nba买球正规nba买球
实验室网址：gaolab.tongji.edu.cn
 

个人简介:
        刘文强，正规nba买球正规nba买球/正规nba买球附属第一妇婴保健院，研究员，博士生导师。上海市母胎医学与妇科肿瘤研究所副所长，获得国家自然科学基金优青项目、上海市青年拔尖人才计划、上海市科技启明星，教育部自然科学奖一等奖。

        2007年毕业于西北农林科技大学，获学士学位；2010年毕业于西北农林科技大学，获硕士学位；2014年毕业于中国农业大学/北京生命科学研究所，获博士学位；2014年8月至今任职于正规nba买球/正规nba买球附属第一妇婴保健院。主要从事早期胚胎发育和人辅助生殖研究。近年来在 Nature，Cell Stem Cell，Cell Reports，Cell Discovery等知名学术期刊发表论文 20 余篇。

发表论文：

1.Yang G#, Zhang L#, Liu W#, Qiao Z, Shen S, Zhu Q, Gao R, Wang M, Wang M, Li C, Liu M, Sun J, Wang L, Liu W, Cui X, Zhao K, Zang R, Chen M, Liang Z, Wang L, Kou X, Zhao Y, Wang H, Wang Y, Gao S*, Chen J*, Jiang C*. Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer.Cell Stem Cell. 2021 Jan 7;28(1):150-163.

2.Li Y, Weng Y, Bai D, Jia Y, Liu Y, Zhang Y, Kou X, Zhao Y, Ruan J, Chen J, Yin J, Wang H, Teng X, Wang Z, Liu W*, Gao S*. Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation.Nat Commun. 2020 Sep 14;11(1):4593.

3.Zhao C#, Zhang N#, Zhang Y#, Tuersunjiang N, Gao S, Liu W*, Zhang Y*. A DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos.Genome Biol. 2020 Nov 16;21(1):277.

4.Bai D#, Sun J#, Jia Y#, Yin J, Zhang Y, Li Y, Gao R, Du X, Li K, Lin J, Tu Z, Wang Y, Pan J, Liang S, Guo Y, Ruan J, Kou X, Zhao Y, Wang H, Jiang C, Wang F, Teng X*, Liu W*, Gao S*. Genome transfer for the prevention of female infertility caused by maternal gene mutation.J Genet Genomics. 2020 Jun 20;47(6):311-319.

5.Liu Y#, Zhang Y#, Yin J, Gao Y, Li Y, Bai D, He W, Li X, Zhang P, Li R, Zhang L, Jia Y, Zhang Y, Lin J, Zheng Y, Wang H, Gao S*, Zeng W*, Liu W*. Distinct H3K9me3 and DNA methylation modifications during mouse spermatogenesis.J Biol Chem. 2019 Dec 6;294(49):18714-18725.

6.Rui Gao#, Chenfei Wang#, Yawei Gao#, Wenchao Xiu, Jiayu Chen, Xiaochen Kou, Yanhong Zhao, Yuhan Liao, Dandan Bai, Zhibin Qiao, Lei Yang, Mingzhu Wang, Ruge Zang, Xiaoyu Liu, Yanping Jia, Yanhe Li, Yalin Zhang, Jiqing Yin, Hong Wang, Xiaoping Wan,Wenqiang Liu*, Yong Zhang*, Shaorong Gao*. Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos.Cell Stem Cell, 2018,23 (3), 426-435

7.Xiaoyu Liu#, Chenfei Wang#, Wenqiang Liu#, Jingyi Li#, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang*, Yawei Gao*&Shaorong Gao*. Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos. Nature, 2016, 537, 558–562

8.Wenqiang Liu, Jiqing Yin, Xiaochen Kou, Yonghua Jiang, Haibo Gao, Yanhong Zhao, Bo Huang, Wenteng He, Hong Wang, Zhiming Han*, and Shaorong Gao* Asymmetric reprogramming capacity of parental pronuclei in mouse zygotes.Cell reports, 2014, 6 (6): 1008-1016 7.9

9.Wenqiang Liu#, Xiaoyu Liu#, Chenfei Wang#, Yawei Gao#*, Rui Gao, Xiaochen Kou, Yanhong Zhao, Jingyi Li, You Wu, Wenchao Xiu, Su Wang, Jiqing Yin, Wei Liu, Tao Cai, Hong Wang, Yong Zhang*, Shaorong Gao*. Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing.Cell Discovery, 2016, 2：16010

10.Wenqiang Liu#, Kunming Li#, Dandan Bai#, Jiqing Yin#, Yuanyuan Tang, Fengli Chi, Linfeng Zhang, Yu Wang, Jiaping Pan, Shanshan Liang, Yi Guo, Jingling Ruan, Xiaochen Kou, Yanhong Zhao, Hong Wang, Jiayu Chen*, Xiaoming Teng*, Shaorong Gao*. Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility.Human Genetics, 2017, 136 (8), 975-985

11.Yi Guo#, Wen qiang Liu#, Yu Wang, Jiaping Pan, Shanshan Liang, Jingling Ruan, Xiaoming Teng*. Polarization microscopy imaging for the identification of unfertilized oocytes following short-term insemination. Fertility and Sterility, 2017, 108 (1), 78-83

12.Yingfeng Li#, Zhuqiang Zhang#, Jiayu Chen#, Wenqiang Liu, Weiyi Lai, Baodong Liu, Xiang Li, Liping Liu, Shaohua Xu, Qiang Dong, Mingzhu Wang, Xiaoya Duan, Jiajun Tan, Yong Zheng, Pumin Zhang, Guoping Fan, Jiemin Wong, Guo-Liang Xu, Zhigao Wang, Hailin Wang, Shaorong Gao, Bing Zhu*. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.Nature,2018, 564(7734), 136.

13.Bingjie Zhang#, Hui Zheng#, Bo Huang#, Wenzhi Li#, Yunlong Xiang, Xu Peng, Jia Ming, Xiaotong Wu, Yu Zhang, Qianhua Xu, Wenqiang Liu, Xiaochen Kou, Yanhong Zhao, Wenteng He, Chong Li, Bo Chen, Yuanyuan Li, Qiujun Wang, Jing Ma, Qiangzong Yin, Kehkooi Kee, Anming Meng, Shaorong Gao, Feng Xu, Jie Na*&Wei Xie*. Allelic reprogramming of the histone modification H3K4me3 in early mammalian development.Nature, 2016, 537, 553–557

14.Li J#, Shen S#, Chen J#, Liu W, Li X, Zhu Q, Wang B, Chen X, Wu L, Wang M, Gu L, Wang H, Yin J, Jiang C*, Gao S*. Accurate annotation of accessible chromatin in mouse and human primordial germ cells.Cell Res. 2018 Nov;28(11):1077-1089.

15.Wang C#, Liu X#, Gao Y#*, Yang L#, Li C, Liu W, Chen C, Kou X, Zhao Y, Chen J, Wang Y, Le R, Wang H, Duan T, Zhang Y*, Gao S*. Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development.Nat Cell Biol. 2018 May;20(5):620-631.