姓名：陈御

学位：博士

研究领域：衰老与基因组稳定性的调控及干预

联系电话：021-65978116

E-mail： y_chen@tongji.edu.cn

通讯地址：上海市杨浦区四平路1239号医学楼1306室

研究方向：

（1）衰老相关DNA修复的细胞特异性变化及调控机制；

（2）长寿生物基因组稳定性维持与健康衰老策略；

（3）基因组不稳定诱发组织退行性变化的机制与干预。

个人简介：

陈御，本科就读于正规nba买球正规nba买球拔尖人才培养基地，后于正规nba买球直接攻读生物学专业博士，师从毛志勇教授。2021年5月起于正规nba买球附属第一妇婴保健院先后任研究实习员、助理研究员。2023年受聘于正规nba买球正规nba买球任预聘助理教授。陈御博士长期围绕衰老与基因组稳定性调控的交叉领域开展研究工作，建立了基于双色荧光的细胞水平及动物水平DNA修复定量报告系统。陈御博士还基于上述系统解析衰老相关DNA修复调控机制并发展靶向DNA修复的衰老及相关疾病的干预手段。陈御博士主持国家自然科学基金青年项目(2022)及上海市科委扬帆计划(2022)等项目，曾获上海市医学科技奖(2022)、正规nba买球追求卓越奖(2021)、正规nba买球优秀博士论文(2022)等荣誉奖励。

研究内容：

基因组不稳定是衰老的首要标志，而DNA修复是维持基因组稳定性的关键机制。然而，在增龄过程中，DNA修复如何发生细胞特异性的变化，其内在调控机制为何，又如何最终引发器官及个体衰老均存在诸多未知，这也极大地限制了靶向DNA修复对抗衰老及相关疾病的策略的研发。围绕上述科学问题，本人致力于开发DNA修复的定量研究系统，基于此解析衰老及长寿基因调控DNA修复的分子机制；并利用长寿动物模型（裸鼹鼠等）及短寿模型（早衰症等）等揭示基因组稳定性维持在衰老及相关疾病发生中的作用，探索延缓衰老及干预衰老相关疾病的新方法。

代表论文（^#共同第一作者, ^* 共同通讯作者）：

1. Chen Y^#, Zhang H^#, Xu Z^#, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y^*, Gorbunova V^*, Mao Z^*. (2019) A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res. 47(16):8563-8580.

 2. Chen Y, Cui Z, Chen Z, Jiang Y^*, Mao Z^*. (2023) IDDoR: a novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways.  Protein & Cell 14(5):369-375.

 3. Chen Y^#, Chen J^#, Sun X^#, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J^*, Gao S^*, Mao Z^*. (2020) The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells. Aging Cell 19(8):e13185.

 4. Zhang W^#, Chen Y^#, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J^*, Gao S^*, Mao Z^*. (2020) A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing. eLife 9:e56008.

 5. Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z^*. (2020) Fight to the bitter end: DNA repair and aging. Ageing Res Rev 64:101154.

 6. Chen Y^#, Li Z^#, Xu Z^#, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y^*, Mao Z^*. (2018) Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy. Cell Death Dis. 9(4):420.

 7. Zhang H^#, Chen Y^#, Jiang Y, Mao Z. (2022) DNA double-strand break repair and nucleic acid-related immunity. Acta Biochim Biophys Sin. 54(6):828-835. (Invited Review)

 8. Cai Y^#, Song W^#, Li J^#, Jing Y^#, Liang C^#, Zhang L^#, Zhang X^#, Zhang W^#, Liu B^#, An Y^#, Li J^#, Tang B^#, Pei S^#, Wu X^#, Liu Y^#, Zhuang C^#, Ying Y^#, Dou X^#, Chen Y^#, Xiao F^#, Li D^#, Yang R^#, Zhao Y^#, Wang Y^#, Wang L^#, Li Y^#, Ma S^*, Wang S^*, Song X^*, Ren J^*, Zhang L^*, Wang J^*, Zhang W^*, Xie Z^*, Qu J^*, Wang J^*, Xiao Y^*, Tian Y^*, Wang G^*, Hu P^*, Ye J^*, Sun Y^*, Mao Z^*, Kong Q^*, Liu Q^*, Zou W^*, Tian X^*, Xiao Z^*, Liu Y^*, Liu J^*, Song M^*, Han J^*, Liu GH^*. (2022) The landscape of aging. Sci China Life Sci. 65(12):2354-2454. (Invited Review)

 9. Aging Biomarker Consortium; Bao H^#, Cao J^#, Chen M^#, Chen M^#, Chen W^#, Chen X^#, Chen Y^#, Chen Y^#, Chen Y^#, Chen Z^#, Chhetri JK^#, Ding Y^#, Feng J^#, Guo J^#, Guo M^#, He C^#, Jia Y^#, Jiang H^#, Jing Y^#, Li D^#, Li J^#, Li J^#, Liang Q^#, Liang R^#, Liu F^#, Liu X^#, Liu Z^#, Luo O^#, Lv J^#, Ma J^#, Mao K^#, Nie J^#, Qiao X^#, Sun X^#, Tang X^#, Wang J^#, Wang Q^#, Wang S^#, Wang X^#, Wang Y^#, Wang Y^#, Wu R^#, Xia K^#, Xiao F^#, Xu L^#, Xu Y^#, Yan H^#, Yang L^#, Yang R^#, Yang Y^#, Ying Y^#, Zhang L^#, Zhang W^#, Zhang W^#, Zhang X^#, Zhang Z^#, Zhou M^#, Zhou R^#, Zhu Q^#, Zhu Z^#, Cao F^*, Cao Z^*, Chan P^*, Chen C^*, Chen G^*, Chen H^*, Chen J^*, Ci W^*, Ding B^*, Ding Q^*, Gao F^*, Han J^*, Huang K^*, Ju Z^*, Kong Q^*, Li J^*, Li J^*, Li X^*, Liu B^*, Liu F^*, Liu L^*, Liu Q^*, Liu Q^*, Liu X^*, Liu Y^*, Luo X^*, Ma S^*, Ma X^*, Mao Z^*, Nie J^*, Peng Y^*, Qu J^*, Ren J^*, Ren R^*, Song M^*, Songyang Z^*, Sun Y^*, Sun Y^*, Tian M^*, Wang S^*, Wang S^*, Wang X^*, Wang X^*, Wang Y^*, Wang Y^*, Wong CCL^*, Xiang AP^*, Xiao Y^*, Xie Z^*, Xu D^*, Ye J^*, Yue R^*, Zhang C^*, Zhang H^*, Zhang L^*, Zhang W^*, Zhang Y^*, Zhang Y^*, Zhang Z^*, Zhao T^*, Zhao Y^*, Zhu D^*, Zou W^*, Pei G^*, Liu GH^*. (2023) Biomarkers of aging. Sci China Life Sci. 66(5):893-1066. (Invited Review, Cover Article)