张振宁

发布时间：2019-05-08

基本信息：

姓名：张振宁

学位：博士

研究领域：

干细胞与再生生物学（Stem Cell and Regenerative Biology）；

神经疾病及代谢疾病模型及转化医学（Disease Modeling and Translational Medicine）；

电子邮件： znzhang@tongji.edu.cn

通讯地址： 上海市杨浦区赤峰路50号正规nba买球医学楼522室，邮编200092

联系电话：021-65982037

研究方向：

1.神经疾病及代谢疾病的干细胞疾病模型；

2.复杂神经系统内各种细胞分化以及迁移的研究；

3.神经疾病中神经元及星型胶质细胞的作用及其机制；

4.糖尿病性神经病变致病机制；

个人简介：

2004年毕业于吉林大学，获得生物技术专业学士学位； 2009年毕业于中国科学院上海生命科学学院生化与细胞研究所，获得细胞生物学专业博士学位，主要从事神经系统内膜表面离子通道及阿片受体行使功能机制的研究； 2009年-2016年于加州大学圣地亚哥分校从事博士后研究，主要研究方向为诱导多能干细胞的免疫原性、干细胞的干性维持机制、神经疾病的干细胞模型。

获奖情况：

2009 地奥奖学金一等奖

代表性文章：

1.Zhang, Z.N. *, Gong, L. *, Lv, S*., Li, J., Tai, X., Cao, W., Peng, B., Qu, S., Li, W., Zhang, C., et al. (2016). SIK2 regulates fasting-induced PPARalpha activity and ketogenesis through p300. Scientific reports 6, 23317.

2.Zhang, Z.N., Freitas, B.C., Qian, H., Lux, J., Acab, A., Trujillo, C.A., Herai, R.H., Nguyen Huu, V.A., Wen, J.H., Joshi-Barr, S., et al. (2016). Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. Proceedings of the National Academy of Sciences of the United States of America 113, 3185-3190.

3.Zhao, T. *, Zhang, Z.N. *, Westenskow, P.D. *, Todorova, D., Hu, Z., Lin, T., Rong, Z., Kim, J., He, J., Wang, M., Clegg, D.O., Yang, Y.G., Zhang, K., Friedlander, M., Xu, Y. (2015). Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells. Cell Stem Cell. (3):353-9.

4.Li, Z., Lu, H., Yang, W., Yong, J., Zhang, Z.N., Zhang, K., Deng, H., Xu, Y. (2014). Mouse SCNT ESCs have lower somatic mutation load than syngeneic iPSCs. Stem Cell Reports. (4):399-405.

5.Zhang, Z.N. *, Chung, S.K. *, Xu, Z., and Xu, Y. (2014). Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation. Stem Cells. (1):157-65.

6.Westenskow, P.D., Moreno, S.K., Krohne, T.U., Kurihara, T., Zhu, S., Zhang, Z.N., Zhao, T., Xu, Y., Ding, S., and Friedlander, M. (2012). Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPS-derived RPE cells. Invest Ophthalmol Vis Sci 53, 6282-6290.

7.Zhao, T., Zhang, Z.N., Rong, Z., and Xu, Y. (2011). Immunogenicity of induced pluripotent stem cells.Nature 474, 212-215.

8.Han, Q.J., Gao, N.N., Guo, Q., Zhang, Z.N., Yu, W.H., Pan, J., Wang, Q., Zhang, X., and Bao, L. (2013). IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-beta/Smad signaling. J Cell Sci 126, 542-553.

9.He, S.Q. *, Zhang, Z.N. *, Guan, J.S. *, Liu, H.R., Zhao, B., Wang, H.B., Li, Q., Yang, H., Luo, J., Li, Z.Y., et al. (2011). Facilitation of mu-opioid receptor activity by preventing delta-opioid receptor-mediated codegradation. Neuron 69, 120-131.

10.Wang, H.B., Zhao, B., Zhong, Y.Q., Li, K.C., Li, Z.Y., Wang, Q., Lu, Y.J., Zhang, Z.N., He, S.Q., Zheng, H.C., et al. (2010). Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci U S A 107, 13117-13122.

11.Zhang, Z.N. *, Li, Q. *, Liu, C., Wang, H.B., Wang, Q., and Bao, L. (2008). The voltage-gated Na+ channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the beta3 subunit. J Cell Sci 121, 3243-3252.

12.Guan, J.S., Xu, Z.Z., Gao, H., He, S.Q., Ma, G.Q., Sun, T., Wang, L.H., Zhang, Z.N., Lena, I., Kitchen, I., et al. (2005). Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. Cell 122, 619-631.

13.Luan, B., Zhang, Z., Wu, Y., Kang, J., and Pei, G. (2005). Beta-arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappaB activation. EMBO J 24, 4237-4246.

* These authors contribute equally to the paper.

地址：上海市四平路1239号电话：021-65981041 传真：65981041