姓       名: 项耀祖

行政职务：生物医药与技术系系主任

学       位: 博士

导师情况: 博士生导师

研究领域: 心血管疾病、中西医结合

研究方向:

1.心血管生物学与药理学

2.中西医结合防治冠心病

Email： yaozu.xiang@tongji.edu.cn

通讯地址：上海市杨浦区四平路1239号，正规nba买球正规nba买球，邮编200092
 

个人简介
     项耀祖，教授，博士生导师，国家优青（2018）。主要从事心血管病发生机制和中西医结合防治研究。主持国家重点研发计划课题、国家自然科学基金优青项目、面上项目和联合项目等。主要研究成果以第一或通讯作者发表在Blood、JCI、PNAS、JACC BTS、Nucleic Acids Res等学术期刊。曾获ISTH Young Investigators Award、NSTH Science Prize、Imperial Rector’s Award等。

教育和工作经历：

2015.11-至今，正规nba买球正规nba买球/正规nba买球附属东方医院，教授、博导

2012-2015年，美国耶鲁大学医学院，博士后

2008-2012年，英国帝国理工学院，分子血液学，博士

2000-2008年，天津中医药大学，医学学士、医学硕士

代表论文：

1. Jiang K#, Tu Z#, Chen K#, Xu Y, Chen F, Xu S, Shi T, Qian J, Shen L, Hwa J, Wang D, Xiang Y*. Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction. J Clin Invest. 2021 Nov 9:e151268.

2. Yang X, Jiang J, Li Z, Liang J, Xiang Y*. Strategies for mitochondrial gene editing. Comput Struct Biotechnol J. 2021;19:3319-3329

3. Shao X, Wang D, Xu Y, Guo L, Yang H, Zhou J, Liang J, Qian J, Cheng J, Sun L*, Xiang Y*.The high platelet counts as predictor for early foetal demise. Ann Med. 2021 Dec;53(1):1502-1508.

4. Yang Y, Jiang K, Liu X, Qin M*, Xiang Y*.CaMKII in regulation of cell death during myocardial reperfusion injury. Front Mol Biosci. 2021;668129.

5. Li G, Ko CN, Li D, Yang C, Wang W, Yang GJ, Di Primo C, Wong VKW, Xiang Y, Lin L*, Ma DL*, Leung CH*. A small molecule HIF-1α stabilizer that accelerates diabetic wound healing. Nat Commun. 2021;12(1):3363.

6. Wang D, Lv L, Xu Y, Jiang K, Chen F, Qian J, Chen M, Liu G, Xiang Y*. Cardioprotection of Panax Notoginseng saponins against acute myocardial infarction and heart failure through inducing autophagy. Biomed Pharmacother. 2021;136:111287. 

7. Jiang K#, Xu Y#, Wang D, Chen F, Tu Z, Qian J, Xu S, Xu Y, Hwa J, Li J, Shang H, Xiang Y*. Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis. Protein Cell. 2021 Jan 8 doi: 10.1007/s13238-020-00809-4.

8. Shi S, Qin M*, Cai Y, Liu T, Shen B, Yang F, Cao S, Liu X, Xiang Y, Zhao Q, Huang H*, Yang* B, Huang C. Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019. Eur Heart J. 2020;41(22):2070-2079.

9. Lin L, Xu L, Lv W, Han L, Xiang Y, Fu L, Jin M, Zhou R, Chen H, Zhang A*. An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS). PLoS Pathog. 2019;15(6):e1007795.

10. Fu L, Xie C, Jin Z, Tu Z, Han L*, Jin M*, Xiang Y*, Zhang A*. The prokaryotic Argonaute proteins enhance homology sequence-directed recombination in bacteria. Nucleic Acids Res. 2019;47(7):3568-3579.

11. Wang D, Hu X, Lee SH, Chen F, Jiang K, Tu Z, Liu Z, Du J, Wang L, Yin C, Liao Y, Shang H, Martin KA, Herzog RI, Young LH, Qian L*, Hwa J*, Xiang Y*. Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation. JACC Basic Transl Sci. 2018;3(3):350-362.

12. Lee SH, Du J, Stitham J, Atteya G, Lee S, Xiang Y, Wang D, Jin Y, Leslie KL, Spollett G, Srivastava A, Mannam P, Ostriker A, Martin KA, Tang WH, Hwa J*. Inducing mitophagy in diabetic platelets protects against severe oxidative stress. EMBO Mol Med. 2016;8(7):779-95.

13. Xiang Y*, Hwa J*. Regulation of VWF expression, and secretion in health and disease. Curr Opin Hematol. 2016;23(3):288-93.

14. Xiang Y*, Cheng J, Wang D, Hu X, Xie Y, Stitham J, Atteya G, Du J, Tang WH, Lee SH, Leslie K, Spollett G, Liu Z, Herzog E, Herzog RI, Lu J, Martin KA, Hwa J*. Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor. Blood. 2015;125(22):3377-87.

15. Crawley JT, de Groot R, Xiang Y, Luken BM, Lane DA*. Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor. Blood. 2011;118(12):3212-21.

16. Xiang Y, de Groot R, Crawley JT, Lane DA*. Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13). PNAS. 2011;108(28):11602-7.

17. Xiang YZ*. Adrenoreceptors, platelet reactivity and clopidogrel resistance. Thromb Haemost. 2008 Nov;100(5):729-30.

18. Xiang YZ*, Xia Y, Gao XM, Shang HC, Kang LY, Zhang BL. Platelet activation, and antiplatelet targets and agents: current and novel strategies. Drugs. 2008;68(12):1647-64. 

19. Xiang YZ*, Kang LY, Gao XM, Shang HC, Zhang JH, Zhang BL. Strategies for antiplatelet targets and agents. Thromb Res. 2008;123(1):35-49. 

20. Xiang YZ, Shang HC, Gao XM, Zhang BL*. A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytother Res. 2008;22(7):851-8.