张超

发布时间：2019-05-08

姓名：张超

学位：博士

导师情况：博士生导师

E-mail: zhangchao@tongji.edu.cn

联系电话：021-65986676

通讯地址：上海市杨浦区四平路1239号，正规nba买球正规nba买球1112室，邮编200092

研究领域：神经内分泌疾病

研究方向：

神经内分泌疾病包括中枢神经系统内分泌紊乱导致的慢性代谢疾病如肥胖症、厌食症和糖尿病，以及起源于神经内分泌细胞的症状多样复杂且异质性高的神经内分泌肿瘤。本实验室利用多种模式动物和临床样本，结合最前沿的多重单细胞测序、超高分辨率显微镜等技术，采用干湿实验结合的方式，研究神经内分泌疾病发生发展过程中的器官病变、药理学调控、表观遗传和基因组学的动态变化，对疾病的预防、检测和精准个体化治疗具有极为重要的科学价值和临床意义。实验室研究方向包括但不限于以下方向：

1.神经内分泌紊乱：利用小鼠、爪蟾、斑马鱼等模式动物和多重单细胞测序技术研究脊椎动物下丘脑-垂体及肾上腺内分泌紊乱导致的肥胖症的发病机理、器官发育病变以及机体损伤的再生机制，着重关注黑色素皮质激素系统中多个G蛋白偶联受体及其辅助蛋白系统在神经内分泌紊乱疾病发生发展中的系统进化以及药理学调控机制。

2.神经内分泌肿瘤：利用多重单细胞测序和超高分辨率显微镜技术研究神经内分泌肿瘤（如神经母细胞瘤、嗜铬细胞瘤等）发病过程中的肿瘤异质性，着重解析肿瘤内部的免疫微环境，肿瘤干细胞和药物靶向治疗中的染色质动态变化与表观遗传调控机理，同时开展循环肿瘤细胞的临床检测以及精准个体化免疫治疗的转化医学研究。

个人简介：

2004年毕业于清华大学生命科学学院，获学士学位。2012年毕业于美国俄勒冈医科大学沃勒姆学院（Vollum Institute），获博士学位。2012至2014年在美国范德堡大学（Vanderbilt University）医学院从事博士后研究。2014年3月起任正规nba买球正规nba买球教授，博士生导师。先后入选国家青年高层次人才计划，上海高校特聘教授（东方学者），上海市青年科技启明星。

张超教授长期从事人体神经内分泌疾病发病机制的研究，以第一或通讯作者在Science、Advanced Materials、Cell Metabolism、PNAS、Developmental Cell、Protein & Cell（4篇）、Pharmacology & Therapeutics、iScience、Journal of Lipid Research等国际一流期刊发表SCI论文41篇，单篇最高IF 44.4，并申报了多项发明专利。主持国家科技部重点研发计划（课题负责人）、国家自然科学基金面上项目（2项）、国家青年高层次人才计划、上海市教委东方学者、上海市科委青年科技启明星、中央高校基本科研经费等课题20余项。兼任中国细胞生物学学会会员，中国生理协会会员，中国医师协会神经修复学专业委员会下丘脑垂体专家委员会委员，中国整形美容协会干细胞研究与应用分会常务理事及青委会委员, 中国实验动物学会神经科学技术委员会委员。

代表论文：

1. Julien Sebag^#, Chao Zhang^#, Patricia Hinkle, Amanda Bradshaw and Roger Cone^*. Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science, 2013 Jul 19;341(6143):278-81. (#co-first author) (IF: 44.4)

2. Lulu Gong^#, Lining Cao^#, Zhenmin Shen^#, Li Shao, Shaorong Gao, Chao Zhang^*, Jianfeng Lu^* and Weida Li^*. Materials for neural differentiation, trans-differentiation and neurological disease modeling. Advanced Materials, 2018 Apr;30(17):e1705684.(*co-corresponding author) (IF: 27.4)

3. Chao Zhang, Paul Forlano and Roger Cone^*, AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metabolism, 2012 Feb 8;15(2):256-64. (IF: 24.3)

4. Yun Zhao^#, Sharif Rahmy^#, Zhongmin Liu, Chao Zhang^*, Xin Lu^*. Rational targeting of immunosuppressive neutrophils in cancer. Pharmacology & Therapeutics，2020 Aug;212:107556 (IF: 11.4)

5. Chao Zhang, Youngsup Song, Darren Thompson, Michael Madonna, Glenn Millhauser, Sabrina Toro, Zoltan Varga, Monte Westerfield, Joshua Gamse, Wenbiao Chen and Roger Cone^*. Pineal-specific agouti protein regulates teleost background adaptation. Proc Natl Acad Sci U. S. A.,2010 Nov 23;107(47):20164-71. (IF: 10.6)

6. Mengshi Zhang^#, Youwei Chen^#, Hanqian Xu^#, Li Yang, Feng Yuan, Lei Li, Ying Xu, Ying Chen^*, Chao Zhang^*and Gufa Lin^*. Melanocortin receptor 4 (MC4R) signaling regulates vertebrate limb regeneration.Developmental Cell, 2018 Aug 20;46(4):397-409.e5 (IF: 10.7)

7. Yaguang Ren^* and Chao Zhang^*. The excessive response: a preparation for harder conditions. Protein & Cell, 2017 Oct;8(10):707-710. (IF: 10.2)

8. Zhifeng Wang^#, Liu Yang^#, Shen Qu^*and Chao Zhang^*. CRISPR-mediated gene editing to rescue haploinsufficient obesity syndrome. Protein & Cell, 2019 Oct;10(10):705-708. (IF: 10.2)

9. Fengjing Jia, Xuewen Li, Chao Zhang^* and Xueming Tang^*.The expanded development and application of CRISPR system for sensitive nucleotide detection. Protein & Cell, 2020 Sep;11(9):624-629 (IF: 10.2)

10. Jian Li, Sihan Lv, Xinchen Qiu, Jiamin Yu, Junkun Jiang, Yalan Jin, Wenxuan Guo, Ruowei Zhao, Zhen-Ning Zhang^*, Chao Zhang^* and Bing Luan^*. BMAL1 functions as acAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis. Protein & Cell, 2018 Nov;9(11):976-980. (IF: 10.2)

11. Lei Li, Jinye Liang, Cong Zhang, Tiemin Liu*, Chao Zhang*. Peripheral actions and direct central-local communications of the melanocortin 4 receptor signaling. Journal of Sport and Health Science. 2020, In Press (IF: 5.2)

12. Xinchen Qiu, Jian Li, Sihan Lv, Jiamin Yu, Junkun Jiang, Jindong Yao, Yang Xiao, Bingxin Xu, Haiyan He, Fangfei Guo, Zhen-Ning Zhang^*, Chao Zhang^*and Bing Luan^*. HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation. Journal of Lipid Research, 2018 Feb;59(2):330-338. (IF: 5.3)

13. Zhiting Wei, Chi Zhou, Zhanbing Zhang, Ming Guan, Chao Zhang^*, Zhongmin Liu^* and Qi Liu^*. The landscape of tumor fusion neoantigens: A pan-cancer analysis. iScience. 2019 Nov 22;21:249-260. (IF 4.4)

14. Jinye Liang^#, Lei Li^#, Xuanxuan Jin, Bingxin Xu, Linyu Pi, Shangyun Liu, Wei Zhu, Cong Zhang, Bing Luan, Lulu Gong^* and Chao Zhang^*. Pharmacological effect of human melanocortin 2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors. Endocrine, 2018 Jul;61(1):94-104 (IF: 3.8)

15. Ming Zhu^#, Meng Wang^#, Yijun Chen and Chao Zhang^*. Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish.Journal of Molecular Endocrinology, 2018 Oct 1. pii: JME-18-0104.R2. doi: 10.1530/JME-18-0104. (IF 3.7)

16. Duohui Jing^*, Yizhou Huang, Xiaoyun Liu, Keith Sia, Julia Zhang, Xiaolu Tai, Meng Wang, Cara Toscan, Hannah McCalmont, Kathryn Evans, Chelsea Mayoh, Rebecca Poulos, Miriam Span, Jianqing Mi, Chao Zhang, Jason Wong, Dominik Beck, John Pimanda and Richard Lock^*. Lymphocyte-specific chromatin accessibility pre-determines glucocorticoid resistance in acute lymphoblastic leukemia.Cancer Cell. 2018 Dec 10;34(6):906-921.e8. (Cover Story, IF:30.2)

17. Bing Duan, Chi Zhou, Chenyu Zhu, Yifei Yu, Gaoyang Li, Shihua Zhang, Chao Zhang, Xiangyun Ye, Hanhui Ma, Shen Qu, Zhiyuan Zhang, Ping Wang^*, Shuyang Sun^* and Qi Liu^*. Model-based understanding of single-cell CRISPR screening. Nature Communications, 2019, May 20;10(1):2233. (IF:13.8)

18. Jifang Yan, Guohui Chuai, Chi Zhou, Chenyu Zhu, Jing Yang, Chao Zhang, Feng Gu, Han Xu, Jia Wei^* and Qi Liu^*. Benchmarking CRISPR on-target sgRNA design. Briefings in Bioinformatics. 2018 Jul 20;19(4):721-724. (IF:9.6)

课题组常年招聘助理教授，博士后，研究助理；并欢迎博士生，硕士生，本科生报考和实习。

地址：上海市四平路1239号电话：021-65981041 传真：65981041